Protein Details: Amiloride-sensitive sodium channel subunit alpha
Protein ID
ICDB_Pro_1365
Protein Name
Amiloride-sensitive sodium channel subunit alpha
Gene Name
SCNN1A; ENAC
Organism
Gallus gallus (Chicken)
Length
637 amino acids
AlphaFoldDB
AF-Q92075-F1-model_v4.pdb
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water; which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis; but also in airway surface liquid homeostasis; which is important for proper clearance of mucus.
Sequence
MGTASRGGSVKAEKMPEGEKTRQCKQETEQQQKEDEREGLIEFYGSYQDVFQFFCSNTTIHGAIRLVCSKKNKMKTAFWSVLFILTFGLMYWQFGILYREYFSYPVNLNLNLNSDRLTFPAVTLCTLNPYRYSAIRKKLDELDQITHQTLLDLYDYNMSLARSDGSAQFSHRRTSRSLLHHVQRHPLRRQKRDNLVSLPENSPSVDKNDWKIGFVLCSENNEDCFHQTYSSGVDAVREWYSFHYINILAQMPDAKDLDESDFENFIYACRFNEATCDKANYTHFHHPLYGNCYTFNDNSSSLWTSSLPGINNGLSLVVRTEQNDFIPLLSTVTGARVMVHDQNEPAFMDDGGFNVRPGIETSISMRKEMTERLGGSYSDCTEDGSDVPVQNLYSSRYTEQVCIRSCFQLNMVKRCSCAYYFYPLPDGAEYCDYTKHVAWGYCYYKLLAEFKADVLGCFHKCRKPCKMTEYQLSAGYSRWPSAVSEDWVFYMLSQQNKYNITSKRNGVAKVNIFFEEWNYKTNGESPAFTVVTLLSQLGNQWSLWFGSSVLSVMELAELILDFTVITFILAFRWFRSKQWHSSPAPPPNSHDNTAFQDEASGLDAPHRFTVEAVVTTLPSYNSLEPCGPSKDGETGLE
PDB Structures
Ligand Binding
Binding Site
Disease
Location
The long isoform has been found in cochlea; colon; and cartilage. The short isoform is only found in cochlea.
DOI ID
10.1016/s0167-4781(96)00197-2
RefSeq
NP_990476.2